Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Also refer to section 4.4, Special warnings and precautions for use. Patients with altered heparin responsiveness or heparin resistance may require disproportionately higher doses of heparin to achieve the desired effect. Maintenance: 1-2,000 units/hour, adjusted to maintain clotting time >40 minutes. Initially 300 units/kg intravenously, adjusted thereafter to maintain the activated clotting time (ACT) in the range 400-500 seconds. In extracorporeal circulation and haemodialysis Prophylaxis of mural thrombosis following myocardial infarctionġ2,500 units 12 hourly subcutaneously for at least 10 days. Or 100 units/kg 4-hourly by intravenous injectionĭaily laboratory monitoring (ideally at the same time each day, starting 4-6 hours after initiation of treatment) is essential during full-dose heparin treatment, with adjustment of dosage to maintain an APTT value 1.5-2.5 x midpoint of normal range or control value. Date of first authorisation/renewal of the authorisationġ5-25 units/kg/hour by intravenous infusion, 6.6 Special precautions for disposal and other handling.4.7 Effects on ability to drive and use machines.4.5 Interaction with other medicinal products and other forms of interaction.4.4 Special warnings and precautions for use.4.2 Posology and method of administration.Show table of contents Hide table of contents
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